SCIENCE BEHIND DIET PLANS AND ITS FAILURE !!

There is no sincere love than the love of food.

ARE YOU ON A DIET PLAN AND CAN'T RESIST EATING ??

 In this world there are many people who are trying hard to deprive them from this feeling

We struggle with eating healthily, obesity and access to good nutrition for everyone but we have a great opportunity to get on the right side of the battle by beginning to think differently about the way that we eat and the way that we approach food.

But if you cant seem to stop munching on yummicious cakes chocolates or any other lip smacking dishes then stop blaming yourself it’s just the way you evolved

Researchers have found that a set of neurons is responsible for the unpleasant feelings associated with hunger that make snacking irresistible.

Scientists at the Howard Hughes Medical Institute's Janelia Research Campus said the AGRP neurons in the hypothalamus make sense from an evolutionary point of view

From an evolutionary point of view, the feeling makes perfect sense – it would have caused us to put effort into searching for food at a time when it was not readily available. Not all our searches would have proved successful, so weight gain would have been unlikely. For the first time ever, we are faced with the difficult situation of having to ignore our natural inclinations if we want to stay slim. 

"We suspect that these neurons are a very old motivational system to force an animal to satisfy its physiological needs. Part of the motivation for seeking food is to shut these neurons off," explained Scott Sternson, one of the lead researchers involved.

In an environment where food is readily available, their difficult-to-ignore signal may seem like an annoyance but for earlier humans or animals in the wild, pursuing food or water can mean venturing into a risky environment, which might require some encouragement, researchers said. 

AGRP neurons do not directly drive an animal to eat, but rather teach an animal to respond to sensory cues that signal the presence of food. 

AGRP neurons are known to be clearly involved in feeding behaviours: When the body lacks energy, AGRP neurons become active, and when AGRP neurons are active, animals eat. 

Postdoctoral researcher Nicholas Betley and graduate student Zhen Fang Huang Cao in a series of behavioural experiments offered well-fed mice two flavoured gels - one strawberry and the other orange. Neither gel contained any nutrients, but the hungry mice sampled them both.

Then the scientists' manipulated the hunger signals in the animals' brains by switching AGRP neurons on while they consumed one of the two flavours. In subsequent tests, the animals avoided the flavour associated with the false hunger signal.

In a reverse experiment, the scientists switched AGRP neurons off while hungry animals consumed a particular flavour. The animals developed a preference for the flavour choice that led to silencing of AGRP neurons, suggesting they were motivated to turn off the cells' unpleasant signal.

In further experiments, the scientists found that mice also learn to seek out places in their environment where AGRP neurons had been silenced and avoid places where those cells were active.

Next, postdoctoral researcher Shengjin Xu used a tiny, mobile microscope to peer inside the brains of hungry mice and monitor the activity of AGRP neurons. As expected, the cells were active until the mice found food. 

What was surprising, Sternson said, is that mice did not actually have to eat to quiet the neurons. Instead, the cells ceased activity as soon as an animal saw food - or even a signal that predicted food. And their activity remained low while the animal was eating. 

That wouldn't make sense if the job of AGRP neurons was to make food taste better or if they directly controlled the individual actions that go into eating, which were two possibilities, said Scott Sternson, group leader at Janelia

So it is not you but the hunger sensitive cells in your brain which are making your “going slim” task difficult.